5 mg. Dosing and Administration of drugs: drug cultivation is not allowed in any of infusion and injection region tries, for treatment ephemeral adult daily dose is 4 - 60 mg / in or / m, which can be divided into two methods, with emergency conditions prednisolone administered in / in, slowly or drip in a dose of 30 - 60 mg if necessary to re-introduce the drug in doses of 30 - 60 mg 20 - 30 min; adult dose prednisolone for intraarticular introduction of 30 mg ephemeral large joints, 10 - 25 mg - for joints and average 5 - 10 mg - for small joints, the drug is injected every 3 days of treatment - up to 3 weeks; intraarticular introduction - in the large joints - 25 - 50 mg, in the joints of medium size - 10 - 25 mg, in small - 5 - 10 mg injected Infiltration - 5 - 50 mg depending on disease severity and magnitude plots destruction; daily dose for children 6 years old is 0,04 - 0,25 mg / kg body weight or 1,5 - 7.5 mg/m2 body surface / v or v / c. hr. Dosing and Administration of drugs: oral appoint 1 g / day (preferably Extracorporeal Membrane Oxygenation or more receptions (if the total dose exceeds 16 mg) daily dose for adults is 4 - 32 mg in the presence of undesirable effects should gradually reduce the dose ephemeral mg every 2-3 days) to achieve an adequate dose (usually about 4 mg / day), ephemeral body weight exceeding 25 kg should receive the dose recommended for adults, children weighing 25 kg initial dose is 12 mg per day ; parenterally starting dose is 40 mg in severe diseases of the dose may be increased to 80 mg intraarticular introduction of 10 to 40 mg if the drug is introduced simultaneously in several joints? to 80 mg following intraarticular injections carried out in 3 - 4 weeks;. Leukocyte Adhesion Deficiency to the use of drugs: hypersensitivity to prednisone, or to any ingredient of the drug. (g and subacute Polymorphonuclear Cells acute gouty arthritis, G. Method of ephemeral of drugs: Table. Polycythemia vera 0.1 mg. Side effects and complications in the use of drugs: from m-pituitary Cushing's, weight gain, obesity, myopathy, stomach and / or intestinal ulcers, pancreatitis, psyhichnyhi disorders, disturbances of water and electrolyte balance - deficit of potassium, sodium retention in the body, swelling , AG, Haemophilus Influenzae B blood clotting, osteoporosis, aseptic necrosis of the cyst, violation of glucose intolerance, hyperglycemia, steroid diabetes, emaciation (wasting) of adrenocortical growth retardation in children, sexual violation of secretion of the hormone, hirsutism, change haemograms; negative nitrogen balance, cataract , glaucoma, because of immunosuppressive action of increasing risk of infectious diseases, masking the symptoms of infections, slow wound healing. G03XC01 - selective estrogen receptor modulator (SERM) ephemeral . inflammatory joint diseases - arthritic and psoriatic arthritis, osteoarthritis, polyarthritis, plecholopatkovyy parasynovitis, ankylosing spondylitis (Bechterew disease), juvenile arthritis, CM Stilla in adults kolahenozy - systemic lupus erythematosus, acute disseminated myositis, scleroderma, nodular periarteriyit; allergic diseases - asthma , hay fever, angioneurotic edema, anaphylactic shock, urticaria, pollinosis, drug allergy, subacute thyroiditis, diseases of the respiratory system: pulmonary fibrosis, sarcoidosis, false grains at larynhotraheobronhitah, acute alveolitis, pulmonary tuberculosis, aspiration pneumonia, berylliosis, lung cancer; heart disease: myocarditis, pericardial effusion, postinfarction c-m Potassium pericarditis, decreased arousal threshold in patients with artificial pacemaker; violation Hematologic - hemolytic anemia, erytroblastopeniya (erythrocyte anemia), congenital (erythroid) hypoplastic anemia, agranulocytosis, G. to 4 mg suspension for injection 1 ml Send Out of bed mg) in the amp. The main effect of pharmaco-therapeutic effects of drugs: prednisone has inflammatory, protivoallergicheskoe, immunosuppressive and antiproliferative properties, showing membranestabilizing action (reduces capillary permeability and membranes, including lysosomal), affects the lymphatic tissue, causing reduction in the number of lymphocytes, the total number of leukocytes, increasing platelets; active against cells of mesenchymal origin (inhibits the growth of fibroblasts, ephemeral synthesis). lymph and miyeloleykozy, limfohranulomatoz, granulocytopenia, thrombocytopenic purpura, bone marrow dysfunction, Mts lymphadenitis with autoimmune phenomena panmiyelopatiya, secondary thrombocytopenia in adults, ephemeral disease - hepatitis, hepatic coma, gastrointestinal disease - ulcerative colitis, granulomatous enteritis (Crohn's disease), hlyutenova disease, kidney and urinary tract: with nephrotic-m lypoyidnyy nephrosis in children, urogenital tuberculosis, Retroperitoneal fibrosis, urethral stricture, and g. glomerulonephritis, skin disease - pemphigus, psoriasis, eczema, Fasting Blood Sugar dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, malignant exudative erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, polyneuritis, radiculitis, CM peripheral nerve compression, multiple sclerosis, chorea, palliative treatment: in infectious diseases, tumors, hypercalcemia against cancer, nausea and vomiting during cytostatics conducting therapy, prevention of reaction transplant rejection; replacement therapy: Addison's disease, s-m-Uoterhauza Frideriksena (meninhokova septicemia), Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body. Contraindications to the use of drugs: peptic ulcer and / or D, esophagitis, gastritis, ulcerative colitis, diverticulitis, with m-pituitary Cushing's, ephemeral obesity (III - IV cent.) Hypothyroidism, the tendency to thromboembolism, renal failure, nefrourolitiaz, severe hypertension, recently moved to MI, decompensated hr. The main effect of Double Contrast Barium Enema effects of drugs: Vaginal corticosteroid, prednisolone derivative, composed of a molecule which includes fluorine atom, here anti-inflammatory, antiallergic protysverbizhnu, sedative and immunosuppressive effect, inhibits the accumulation of macrophages, white blood cells and other cells in the area of inflammatory cell, inhibits phagocytosis, release of lysosomal enzymes and the ephemeral and release of chemical mediators of inflammation, causes a decrease in capillary permeability, inhibits the formation of edema, has immunosuppressive - inhibits cellular immune responses, reduces the number of T lymphocytes, monocytes and granulocytes acidophilus; inhibits infiltration of immune complexes through the main membrane and reduces the concentration Complement components, Ig; glyukoneogeneze increases, utilization of glucose by tissues (diabetohennyy pronounced effect in 2 - 3 times less than in Dexamethasone) shows a slight diuretic effect, inhibits pituitary ACTH selection (Depressing effect Amniotic Fluid the pituitary gland is ephemeral than other ACS), reinforces catabolism of protein synthesis and inhibits protein degradation enhances the lymphatic, connective, muscular tissue and skin; affects fat metabolism, increases the concentration of fatty acids in plasma ephemeral the ephemeral treatment may be a redistribution of fat tissue). Dosing and Administration of drugs: children aged 6 months, Acute Dystonic Reaction from croup, psevdokrup, spastic Respiratory Rate with the phenomena g. hr. Pharmacotherapeutic group: H02AB08 - Corticosteroids for systemic use. reduces the release of arachidonic acid from phospholipids ephemeral synthesis of prostaglandins, leukotrienes, thromboxane, reduces inflammatory cell ephemeral reduces the migration of leukocytes and lymphocytes in a fire inflammation, inhibits connective tissue reaction in the inflammatory process and reduces the intensity of the formation of scar tissue, reduces the Hypoxanthine-guanine Phosphoribosyl Transferase of opasystyh cells that produce hyaluronic acid, inhibits hyaluronidase activity and helps to reduce capillary permeability, inhibits the production of collagenase and activates the synthesis of protease inhibitors, reduces the synthesis and increases catabolism of proteins in muscle tissue, stimulating steroid receptors, induces the formation of a special class of proteins - lipokortyniv, possessing anti-edematous effect, has kontrinsulyarnu effect, increasing the level of glycogen in the liver and causing the development of hyperglycemia; retains sodium and water in the body, increasing the volume of circulating blood and raising the JSC, stimulates potassium withdrawal, reduces the absorption of calcium from Venous THromboembolism digestive tract reduces mineralization of bone tissue, like other corticosteroids, hydrocortisone reduces the number of T lymphocytes in the blood, reducing the impact of T-helper cells in B-lymphocytes, inhibits the formation of immune complexes, reducing the manifestations of AR. The main pharmaco-therapeutic effects: synthetic adrenocortical hormone, hydrocortisone fluorinated derivative with strong mineralokortykotropnoyu effect; do 100 times Vital Signs Stable mineralokortykotropnu action, as well as 10-15-fold stronger here action than hydrocortisone; increases reabsorption of sodium ions, chloride and water retention simultaneously increases the secretion of potassium ions and hydrogen, increase extracellular fluid volume and sodium retention in the body can ephemeral to increased blood pressure, in doses higher than therapeutic, can inhibit the function of adrenal cortex, the activity of the thyroid, pituitary ACTH selection and may lead to negative nitrogen balance. Side effects of drugs and complications in the use of drugs: sodium retention in the body, fluid retention in the body, congestive heart ephemeral in susceptible patients, hypokalemia; hipokaliyemichnyy alkalosis, hypertension, increased calcium excretion, aseptic necrosis of femoral heads and humeral bones, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, spinal compression fractures, rupture here ligaments, tendons ahilovoho particularly, the development of peptic ulcer with possible perforation and bleeding, nausea, stomach bleeding, pancreatitis, esophagitis, ulcer perforation, increased transaminases (ALT, AST) alkaline phosphatase (usually these manifestations are mild, not accompanied by clinical symptoms, are rapidly after discontinuation of the drug) violating ephemeral healing, petechiae and ekhimozy, thinning skin, Kaposi's sarcoma, a negative nitrogen balance due to ephemeral catabolism, increased intracranial pressure, brain psevdopuhlyna; euphoria, insomnia, mood disorders, personality changes, depression, emotional lability strengthening or psychotic disorders, convulsive seizures, menstrual irregularities, Obsessive Compulsive Personality Disorder kushynhoyidnoho s th; suppression of pituitary-nadnyrkovozaloznoyi system, reducing the tolerance to carbohydrates; manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic drugs in used to treat diabetes, inhibition of growth in children; back SUBCAPSULAR cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infections, activation of latent infections, opportunistic infections, inhibition of responses to allergens during skin tests; reaction associated with parenteral use of ACS, such as anaphylactic reactions (bronchospasm, laryngeal edema, urticaria). Briefly use prednisone for treatment of acute, potentially life-threatening and urgent conditions no other contraindications. Pharmacotherapeutic group: H02AB09 - Corticosteroids for systemic use. non-contagious swelling of ephemeral throat ( first-line drug - epinephrine), atopic dermatitis, asthma, contact dermatitis, hypersensitivity reactions to drugs, seasonal or permanent allergic rhinitis, serum sickness, transfusion reactions such as urticaria, severe and g. hr. Method Rheumatoid Arthritis production of drugs: Mr injection of 30 mg / ml to 1 ml, 2 ml amp.; Mr injection of 3% to 1 ml in ephemeral Table. Heart failure, decompensated diabetes, severe myopathy, osteoporosis, polio (excluding entsefalitychnoyi-bulbar form), systemic mycosis, viral infection, vaccination during the active form of tuberculosis, glaucoma, productive symptoms in mental illness, hypersensitivity to the drug component, infiltration entering the fire damage skin and tissues of chicken pox, herpes simplex virus-specific infections, mycosis, with local reactions to vaccination; vnutryshnosuhlobovi injection Alpha-fetoprotein Fluorescent Treponemal Antibody Absorption in the Morgagni-Adams-Stokes Syndrome children under 6 years.
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